Bee and Puppycat revolves around its protagonist, Bee, a sort of young man in his 20s drifting between temporary jobs on a pale-colored fantasy island. When visited by her chibi companion, Puppycat, she is recruited for a series of interstellar missions for many endearing strange alien creatures in a really big way. Juggling these strange and whimsical quests with perhaps equally quirky inhabitants of the island.